![]() ![]() This property results in the increase in signal intensity of normal hepatic parenchyma. Mangafodipir trisodium (Mn-DPDP) is specifically taken up by hepatocytes due to its chemical similarity to vitamin B 6. It goes by the trade name Primovist (Eovist/Bayer). The delayed imaging time is also more convenient (10-20 minutes). Compared to gadobenate, it has more intense liver parenchymal enhancement. It has almost equal biliary and renal excretion (~50% each). G adoxetate disodium (Gd-EOB-DTPA): has protein binding of <10%. Its delayed imaging time is between 90 to 120 minutes.ī. It goes by the trade name MultiHance (Bracco). G adobenate disodium (Gd-BOPTA): weak and transient protein bonding (<5%) and only 2-4% of it is taken up by the liver cells. Additionally, the biliary excretion enables biliary ductal mapping (post-contrast MRCP/ functional MRCP) using 3D T1 weighted fat-saturated GRE images.Ī. Thus, the enhancement of lesions in the hepatobiliary phase depends on the expression and activity of these transporters, depending on the presence or absence of functioning hepatocytes.ĭuring the hepatobiliary phase, they selectively increase the liver signal intensity and aid the in the detection of small tumors. The absorption by hepatocytes is via the OATP1 transporter (polypeptide adenosine triphosphate-dependent organic anion transporter), the same as the bilirubin transporter. However, in the delayed (hepatobiliary) phase, they are taken up by the liver as their excretion is not only through the renal but the hepatic route as well. These agents initially act like non-specific extracellular gadolinium chelates post bolus injection and show three primary phases of vascular and tissue enhancement (arterial, blood pool and extracellular phases). Hepatobiliary specific gadolinium agents include two of the high relaxivity agents: gadobenate disodium (Gd-BOPTA) and gadoxetate disodium (Gd-EOB-DTPA).īiochemically, these agents are linear ionic molecules and show higher T1 relaxivity (>6.5 L/mmol/s at 1.5 T) as compared to the other Gd chelates (<4.8 L/mmol/s at 1.5 T). high relaxivity agents (bind to serum proteins).non-specific extracellular gadolinium chelates (do not bind to serum proteins). ![]() Gadolinium (Gd) based contrast agents are classified into:
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